Engineering a DNA World

California Institute of Technology
Center for Biological Circuit Design
Rock Auditorium, Broad Center for Biological Sciences
Pasadena, California

January 6 - 8, 2005


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This workshop will explore the possibility of engineering sophisticated molecular systems in which all major functional roles are played by nucleic acids.

Can the complexity of the RNA world be reproduced, with molecular engineering as the goal?

Talks will cover DNA nanotechnology, self-assembly, biomolecular computation and fault-tolerance, computational algorithms for nucleic acid folding and design, molecular motors, nucleic acid thermodynamics and kinetics, ribozymes and in vitro evolution.

Organizing Committee
Niles Pierce (co-chair), Caltech
Ned Seeman, New York University
Milan Stojanovic, Columbia University
Erik Winfree (co-chair), Caltech

Download the poster (pdf) for your department!





Panel discussions will address major challenges that confront nucleic acid engineering, such as predictive modeling and validation, energy delivery for motors and catalysts, experimental techniques and instrumentation, scaling up to complex systems, and self-replication.

Participation as a speaker is by invitation only. The workshop format will include 20 talks, two panel discussions, a poster session, and ample time for informal discussion.

Register online! There is a nominal $20 fee for the banquet; please pay upon check-in. Check or cash only.

Later registration will be considered depending on availability. Register early to ensure a seat. Please email questions to

We have a limited number of travel grants for students and postdoctoral scholars interested in presenting posters. These will be awarded on a competitive basis. If you would like to apply for one of these, please send your half-page poster abstract, contact information, and a brief letter of recommendation from your faculty advisor directly to Earlier applications will be given precendence.


Sponsored by Information Science and Technology (IST) at Caltech, the Center for Biological Circuit Design at Caltech, and the International Society for Nanoscale Science, Computation and Engineering (ISNSCE).