Lulu Qian

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previous Folding DNA into nanostructures

Inspired by Paul Rothemund’s work on DNA origami, we designed and constructed a nanoscale structure in the shape of a China map, folded from a long single-stranded DNA virus genome and over 200 synthesized short strands. We developed software that can generate DNA sequences for folding DNA origami into any desired shape. Our work became the first independent implementation of the DNA origami technique, which has now been widely adopted. We also explored mechanisms to build three-dimensional nanostructures, as well as using DNA nanostructure as a template to build conducting devices. Further work developed the use of this China-map-shaped DNA origami as a solution-phased DNA chip.

[1] Analogic China map constructed by DNA. Lulu Qian, Yin Wang, Lin He, et al. Chinese Science Bulletin, 51:2973-2976, 2006. (pdf)
[2] Asymmetric DNA origami for spatially addressable and index-free solution-phase DNA chips. Zhao Zhang, Yin Wang, Lulu Qian et al. Advanced Materials, 22:2672-2675, 2010. (pdf)